(Photo: Lou Rocco/Getty Images)
In a message on the Microsoft founder's Twitter account, the couple said they made the decision after "a great deal of thought and a lot of work on our relationship".
The couple have three children together - Jennifer, Rory and Phoebe.
Gates, the fourth richest man in the world with a net worth of $130bn (£93bn), married Melinda in January 1994.
In 2000, the couple founded the Bill & Melinda Gates Foundation, which is reported to be the largest private foundation in the world.
The amis of the foundation is to enhance healthcare and reduce extreme poverty across the world.
Melinda Gates was the one to file for divorce from Bill Gates — and the billionaire philanthropist couple apparently did not have a prenuptial agreement, court documents reveal.